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Mutant sequences as probes of protein folding mechanisms

โœ Scribed by C. Robert Matthews; Mark R. Hurle

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
436 KB
Volume
6
Category
Article
ISSN
0265-9247

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โœฆ Synopsis

Mutagenesis makes it possible to examine the effect of amino acid replacements on the folding and stability of proteins. The evaluation of kinetic and equilibrium folding data using reaction coordinate diagrams allows one to determine the roles that single amino acids play in the folding mechanism.

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