𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Mechanism of protein folding

✍ Scribed by O. B. Ptitsyn; A. V. Finkelstein

Publisher
John Wiley and Sons
Year
1979
Tongue
English
Weight
597 KB
Volume
16
Category
Article
ISSN
0020-7608

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The first stage of protein self‐organization—the formation of a fluctuating secondary structure in the unfolded protein chain—is considered. The stereochemical theory is presented enabling one to calculate helix‐coil and β‐structure‐coil equilibrium constants. It is shown that the most probable localization of fluctuating α‐ and β‐structure in the unfolded protein chain corresponds to the native localization of these structures. The formation of large α‐ and β‐structural blocks is observed, each of them including several native α‐helices or β‐strands.

📜 SIMILAR VOLUMES

Mechanism of protein folding
Mechanism of protein folding
✍ Bengt Nölting; Karl Andert 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 666 KB
Protein folding mechanisms and the multi
Protein folding mechanisms and the multidimensional folding funnel
✍ Nicholas D. Socci; José Nelson Onuchic; Peter G. Wolynes 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 475 KB 👁 2 views

An important idea that emerges from the energy landscape theory of protein folding is that subtle global features of the protein landscape can profoundly affect the apparent mechanism of folding. The relationship between various characteristic temperatures in the phase diagrams and landmarks in the

A heteropolymer model study for the mech
A heteropolymer model study for the mechanism of protein folding
✍ Masataka Fukugita; David Lancaster; Mark G. Mitchard 📂 Article 📅 1997 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 913 KB

## 4 It('[['r<)[){]l!fn ('r tnodel (d rundoml~.scll~in(eruc[itrgchuirrs /n [MOdimcn.sitms is .studicd Lt'i[h numericul ,sitnulu(ions {n order [C] ehicida(e th(~.ji]ldingmechanism oj protein. H),find (hat the model occasionally . SIMN{ .S,li~lding propen.si[~,depending on [he .wqacnce ()/" random nam

Statistical mechanics of protein folding
Statistical mechanics of protein folding by exhaustive enumeration
✍ Gordon M. Crippen; Yoshiaki Zenmei Ohkubo 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 216 KB 👁 2 views

It is hard to construct theories for the folding of globular proteins because they are large and complicated molecules having enormous numbers of nonnative conformations and having native states that are complicated to describe. Statistical mechanical theories of protein folding are constructed arou

Mutant sequences as probes of protein fo
Mutant sequences as probes of protein folding mechanisms
✍ C. Robert Matthews; Mark R. Hurle 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 436 KB 👁 1 views

Mutagenesis makes it possible to examine the effect of amino acid replacements on the folding and stability of proteins. The evaluation of kinetic and equilibrium folding data using reaction coordinate diagrams allows one to determine the roles that single amino acids play in the folding mechanism.