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Mechanisms of human CD5 modulation and capping induced by murine monoclonal antibody T101

✍ Scribed by Daniel L. Shawler; Duane E. Johnson; Tammy J. McCallister; Richard M. Bartholomew; Robert O. Dillman

Book ID
118374924
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
841 KB
Volume
47
Category
Article
ISSN
1090-2341

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## Abstract The anti‐pan T cell monoclonal antibody OKT3 was administered daily for 2 weeks in four human renal allograft recipients. The antibody induced a dramatic and immediate depletion of peripheral T cells followed by an __in vivo__ antigenic modulation of the OKT3‐defined membrane antigen: a