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Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody

✍ Scribed by Lucienne Chatenoud; Marc F. Baudrihaye; Henri Kreis; Gideon Goldstein; John Schindler; Jean-Francois Bach

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 345 KB
Volume: 12
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830121116

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The anti‐pan T cell monoclonal antibody OKT3 was administered daily for 2 weeks in four human renal allograft recipients. The antibody induced a dramatic and immediate depletion of peripheral T cells followed by an in vivo antigenic modulation of the OKT3‐defined membrane antigen: after three injections, OKT3‐treated patients showed a limited but significant number of OKT3^−^ cells of T cell nature (as defined by OKT4 and OKT8) which recovered the OKT3 receptor after an overnight in vitro incubation in the absence of the monoclonal antibody.

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