Mechanisms of gene regulation and transformation by epstein barr virus
β Scribed by E. Kieff; E. Robertson; K. Kaye; K. Izumi; C. Miller; R. Yalamanchili; S. Harada; S. Grossman; X. Tong; T. VanArsdale; C. Ware; R. Drabkin; D. Reinberg; G. Mosialos
- Book ID
- 112781446
- Publisher
- Springer-Verlag
- Year
- 1995
- Tongue
- English
- Weight
- 141 KB
- Volume
- 121
- Category
- Article
- ISSN
- 1432-1335
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## Abstract EpsteinβBarr virus (EBV), a ubiquitous human herpes virus, is associated with an increasing number of lymphoid and epithelial malignancies. The ability of the virus to establish lifeβlong persistent infections and induce growth transformation is related to the function of a set of viral
By rosetting with SRBC coupled to rabbit-anti-human IgM, the surface IgM-negative cells of human fetal bone marrow were enriched, and subsequently infected and transformed by Epstein-Barr virus (EBV). Single clones of the transformed cells were obtained. Ninety percent of the resulting cell clones w