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Epstein–Barr virus: Induction and control of cell transformation

✍ Scribed by Riccardo Dolcetti; Maria G. Masucci

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
275 KB
Volume
196
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Epstein–Barr virus (EBV), a ubiquitous human herpes virus, is associated with an increasing number of lymphoid and epithelial malignancies. The ability of the virus to establish life‐long persistent infections and induce growth transformation is related to the function of a set of viral proteins that are variously expressed in both normal and malignant cells. Recent evidence indicates that these viral proteins are able to usurp cellular pathways that promote the cell growth and survival, while impairing anti‐viral immune responses. Elucidation of the mechanisms by which EBV induces cell transformation and escapes host immune control provides the rational background for the design of new strategies of intervention for EBV‐related malignancies. J. Cell. Physiol. 196: 207–218, 2003. © 2003 Wiley‐Liss, Inc.

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