𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cell relationships in transformation of human leukocytes by epstein-barr virus

✍ Scribed by J. H. Pope; W. Scott; D. J. Moss

Publisher
John Wiley and Sons
Year
1974
Tongue
French
Weight
620 KB
Volume
14
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Transformation of human leukocytes by the QIMR‐ WIL strain of EB virus in vitro involves co‐operation between adherent cells (probably macrophages) and non‐adherent cells (predominantly lymphocytes). It was shown that the proliferating cells were derived from the non‐adherent population. Unlike macrophages, autochthonous fibroblasts did not enhance proliferation when cultured with non‐adherent cells, but apparently were inhibitory. A strain of allogeneic fibroblasts was not inhibitory. Inoculation of nonadherent cells with EB virus was essential for transformation, while inoculation of macrophages only was insufficient. It appears from these results that infection of non‐adherent cells with QIMR‐ WIL EB virus induces some cells to proliferate, and that the enhancing role of the macrophage does not involve infection with virus.

📜 SIMILAR VOLUMES

Epstein-barr virus-induced transformatio
Epstein-barr virus-induced transformation of human leukocytes after cell fractionation
✍ Ulrich Schneider; Harald Zur Hausen 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 508 KB

## Abstract The efficiency of transformation of human lymphocytes after infection with Epstein‐Barr virus (EBV) was determined in fractionated and non‐fractionated preparations derived from 16 human cord blood samples and two blood samples from adult donors. The transformation efficiency of macroph

Clonal transformation of human leukocyte
Clonal transformation of human leukocytes by Epstein-barr virus in soft agar
✍ Naoki Yamamoto; Yorio Hinuma 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 518 KB

## Abstract The B95‐8 strain of Epstein‐Barr virus (EBV) induced colony formation of human umbilical cord‐blood leukocytes in soft agar medium. One‐hit response relationship between the number of colonies and the virus dose was observed with high dilutions of the virus preparation. However, there w

Characteristics of cell lines derived fr
Characteristics of cell lines derived from human leukocytes transformed by different strains of epstein-barr virus
✍ Takato Katsuki; Yorio Hinuma 📂 Article 📅 1975 🏛 John Wiley and Sons 🌐 French ⚖ 593 KB

## Abstract Variation of Epstein‐Barr virus (EBV) in respect to its effect on the properties of transformed cells was probed. Human umbilical cord leukocytes from six different individuals were transformed in vitro by either B95‐8 (B) or QIMR‐WIL (Q) strains of EBV and subsequently 12 lymphoblastoi

A quantitative analysis of the susceptib
A quantitative analysis of the susceptibility of human leukocytes to transformation by epstein-barr virus
✍ Takato Katsuki; Yorio Hinuma 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 623 KB

## Abstract Susceptibility of lymphocyte‐enriched cell fractions isolated from human umbilical cord blood and adult peripheral blood to transformation by the B95–8 strain of Epstein‐Barr virus (EBV) was investigated quantitatively. Minimum multiplicity of input of virus (50% transforming dose) per