Mechanisms of enzymatic CO bond cleavages in deoxyhexose biosynthesis
✍ Scribed by Xuemei He; Hung-wen Liu
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 153 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1367-5931
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✦ Synopsis
In the past few years, significant progress has been made in our understanding of the biosynthesis of deoxyhexoses. Mechanistic studies have revealed how enzymes can cleave CbondO bonds of a hexose substrate to make unusual sugars. The increasing amount of knowledge about the biosynthesis of deoxysugars may allow the assembly of a repertoire of novel sugar structures through recruitment and collaborative action of genes from a variety of biosynthetic pathways to create diverse secondary metabolites in our search for novel antibiotic/antitumour agents.
📜 SIMILAR VOLUMES
The incorporation of a stereochemical probe into aryl substituted oxiranylcarbinyl radicals has demonstrated that the C-C bond cleavage in these systems is reversible, and that it can occur even when no products of C-C cleavage are obtained.
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