Mechanisms of c-myc-mediated transcriptional repression of growth arrest genes
โ Scribed by Andrei L Gartel; Ksenya Shchors
- Book ID
- 117099714
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 93 KB
- Volume
- 283
- Category
- Article
- ISSN
- 0014-4827
No coin nor oath required. For personal study only.
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In ยฎssion yeast Schizosaccharomyces pombe, ammonium starvation induces a growth arrest, a cell cycle exit in G 1 and a further switch to meiosis. This process is regulated by the cAMP-dependent protein kinase and the Wis1dependent MAP kinase cascade, and downstream transcription factors. In order to
## Abstract The p27^Kip1^ (p27) cyclinโdependent kinase inhibitor and cโMyc oncoprotein play essential roles in control of cell cycle progression and apoptosis. Induction of __p27__ (__CDKN1B__) gene transcription by Forkhead box O proteins such as FOXO3a leads to growth arrest and apoptosis. Previ