Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells
✍ Scribed by Shizhong Bu; Andree Blaukat; Xin Fu; Nils-Erik Heldin; Maréne Landström
- Book ID
- 117104766
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 593 KB
- Volume
- 531
- Category
- Article
- ISSN
- 0014-5793
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## Abstract 2‐Methoxyestradiol, a well‐known nonpolar endogenous metabolite of 17β‐estradiol, has been shown to selectively induce apoptosis in a number of cancer cell lines, but not in normal cells. The mechanism of 2‐methoxyestradiol‐induced apoptosis appears to vary considerably in different cel
2-Methoxyestradiol (2-ME 2 ) is a novel anticancer agent because of its ability to potentiate apoptotic cell death and inhibit cancer cell growth and angiogenesis. The modes of action of this agent, however, have not yet been fully elucidated. In our study, we have investigated whether 2-ME2 is able
## Abstract It is widely known that death receptor Fas‐dependent apoptotic signals are associated with development of prostate cancer, but the key pathways involved in sensitivity to the apoptosis remain unclear. Here we investigated the molecular mechanism by which 2‐methoxyestradiol (2‐ME) effect