2-Methoxyestradiol Induces G2/M Arrest and Apoptosis in Prostate Cancer
✍ Scribed by Laila R. Qadan; Carlos M. Perez-Stable; Curtis Anderson; Gianluca D'Ippolito; Alan Herron; Guy A. Howard; Bernard A. Roos
- Book ID
- 115588380
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 176 KB
- Volume
- 285
- Category
- Article
- ISSN
- 0006-291X
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## Abstract 2‐Methoxyestradiol (2ME) is an endogenous metabolite with estrogen receptor‐independent anti‐tumor activity. The current study seeks to determine the mechanism of anti‐tumor activity of 2ME on human chondrosarcoma. 2ME caused a time‐ and dose‐dependent cytotoxity in chondrosarcoma cells
## Abstract 2‐Methoxyestradiol, a well‐known nonpolar endogenous metabolite of 17β‐estradiol, has been shown to selectively induce apoptosis in a number of cancer cell lines, but not in normal cells. The mechanism of 2‐methoxyestradiol‐induced apoptosis appears to vary considerably in different cel