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Mechanisms by which oxygen regulates gene expression and cell-cell interaction in the vasculature

โœ Scribed by Kourembanas, Stella; Morita, Toshisuke; Liu, Yuxiang; Christou, Helen

Book ID
109885023
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
617 KB
Volume
51
Category
Article
ISSN
0085-2538

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The gene expression of heme oxygenase-1 (HO-1) was studied in mammalian cell lines exposed to hyperoxia. Northern blot analysis demonstrated that hyperoxic exposure increased the HO-1 mRNA levels in various types of cells, including human hepatoma (HepG2) cells. This increase was time-and dose-depen