## Abstract A single oral dose of diβ__n__βbutyl phthalate (DBP) to male rats caused a sloughing of the germ cells at 6 h, with more severe sloughing at 24 and 48 h. DBP is metabolized to monoβ__n__βbutyl phthalate (MBP), which is transported through the bloodβtubular barrier into the seminiferous
Mechanism of testicular atrophy induced by Di-n-butyl phthalate in rats. part 4. changes in the activity of succinate dehydrogenase and the levels of transferrin and ferritin in the sertoli and germ cells
β Scribed by Masamichi Fukuoka; Tetsu Kobayashi; Yu Zhou; Takao Hayakawa
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 568 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0260-437X
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β¦ Synopsis
A single oral dose of di-n-butyl phthalate (DBP) to male rats caused a sloughing of the germ cells at 6 h both with a decrease in the activity of succinate dehydrogenase (SDH) in the Sertoli cells and in the Sertoli-germ connection and with an increase in the activity of lactate dehydrogenase (LDH) in the germ cells. Increases in transferrin (TO concentrations were observed in the Sertoli cells, Sertoli-germ connection, epididymis-ductus deferens and liver of rats. Decreases in Tf and ferritin (Ft) levels were observed in the seminal vesicle and seminiferous lumen, respectively. An increase in favin adenine dinucleotide (FAD) level was found in the interstitial cells.
π SIMILAR VOLUMES
This study reports changes in levels of ferritin, haemoglobin and transferrin in the bone marrow, liver and spleen as an attempt to determine the causes of testicular iron depletion. A single oral dose of di-n-butyl phthalate (DBP) to male rats caused a sloughing of the germ cells (at 6 h) prior to
Repeated oral doses of di-n-butyl phthalate (DBP) to male rats caused a decrease in testicular fructose and glucose and a sloughing of the germ cells on the first day of treatment. On day 2, more severe sloughing was seen and was accompanied by decreases in testicular iron and zinc levels and increa
Division of Biological Chcmistry. Niition.il Institute ol' Hygienic Scicnccs. Kiimiyo~~i-I-chomc. Sciaga)aLu. l'ohvo 158. Japan