✦ LIBER ✦

Mechanism of testicular atrophy induced by Di-n-butyl phthalate in rats. Part 1

✍ Scribed by Masamichi Fukuoka; Tsuyoshi Tanimoto; Yu Zhou; Nana Kawasaki; Akira Tanaka; Isao Ikemoto; Toyohei Machida

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 740 KB
Volume: 9
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550090413

No coin nor oath required. For personal study only.

✦ Synopsis

Repeated oral doses of di-n-butyl phthalate (DBP) to male rats caused a decrease in testicular fructose and glucose and a sloughing of the germ cells on the first day of treatment. On day 2, more severe sloughing was seen and was accompanied by decreases in testicular iron and zinc levels and increases in the level of inositol and cholesterols. The sloughing was followed by atrophy, accompanied by dissociation of the germ cells from the Sertoli cells and reduction of triglycerides, cholesterols and phospholipids containing choline and ethanolamine residues in the testis.

Receivd I0 Jii1.v Acceppred I0 Jariuary

📜 SIMILAR VOLUMES

Mechanism of testicular atrophy induced

Mechanism of testicular atrophy induced by Di-n-butyl phthalate in rats. Part 2. The effects on some testicular enzymes

✍ Masamichi Fukuoka; Yu Zhou; Akira Tanaka; Isao Ikemoto; Toyohei Machida 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 758 KB

Division of Biological Chcmistry. Niition.il Institute ol' Hygienic Scicnccs. Kiimiyo~~i-I-chomc. Sciaga)aLu. l'ohvo 158. Japan

Mechanism of testicular atrophy induced

Mechanism of testicular atrophy induced by di-n-butyl phthalate in rats. Part 5. Testicular iron depletion and levels of ferritin, haemoglobin and transferrin in the bone marrow, liver and spleen

✍ Masamichi Fukuoka; Tetsu Kobayashi; Takao Hayakawa 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 735 KB

This study reports changes in levels of ferritin, haemoglobin and transferrin in the bone marrow, liver and spleen as an attempt to determine the causes of testicular iron depletion. A single oral dose of di-n-butyl phthalate (DBP) to male rats caused a sloughing of the germ cells (at 6 h) prior to

Mechanism of testicular atrophy induced

Mechanism of testicular atrophy induced by Di-n-butyl phthalate in rats. part 4. changes in the activity of succinate dehydrogenase and the levels of transferrin and ferritin in the sertoli and germ cells

✍ Masamichi Fukuoka; Tetsu Kobayashi; Yu Zhou; Takao Hayakawa 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 568 KB

A single oral dose of di-n-butyl phthalate (DBP) to male rats caused a sloughing of the germ cells at 6 h both with a decrease in the activity of succinate dehydrogenase (SDH) in the Sertoli cells and in the Sertoli-germ connection and with an increase in the activity of lactate dehydrogenase (LDH)

Mechanisms of testicular atrophy induced

Mechanisms of testicular atrophy induced by Di-n-butyl phthalate in rats. Part 3. Changes in the activity of some enzymes in the sertoli and germ cells, and in the levels of metal ions

✍ Yu Zhou; Masamichi Fukuoka; Akira Tanaka 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 645 KB

## Abstract A single oral dose of di‐__n__‐butyl phthalate (DBP) to male rats caused a sloughing of the germ cells at 6 h, with more severe sloughing at 24 and 48 h. DBP is metabolized to mono‐__n__‐butyl phthalate (MBP), which is transported through the blood‐tubular barrier into the seminiferous

Role of zinc in regulating the testicula

Role of zinc in regulating the testicular function Part 3. Histopathological changes induced by dietary zinc deficiency in testes of male albino rats

✍ Hafiez, A. A. ;El-Kirdassy, Z. H. M. ;El-Malkh, N. M. ;El-Zayat, E. M. I. 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 606 KB

Zinc deficiency affects the testicular tissues adversely. The testes of zinc-deficient rats showed variable degrees of degeneration compared to both control and zinc-supplemented ones. Initially, there was an early pronounced spermatic arrest followed by a series of degeneration of the cellular laye