Mechanism of Replication-Coupled DNA Interstrand Crosslink Repair
✍ Scribed by Markus Räschle; Puck Knipscheer; Milica Enoiu; Todor Angelov; Jingchuan Sun; Jack D. Griffith; Tom E. Ellenberger; Orlando D. Schärer; Johannes C. Walter
- Book ID
- 116354079
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 31 KB
- Volume
- 137
- Category
- Article
- ISSN
- 0092-8674
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## Abstract DNA damage by agents crosslinking the strands presents a formidable challenge to the cell to repair for survival and to repair accurately for maintenance of genetic information. It appears that repair of DNA crosslinks occurs in a path involving double strand breaks (DSBs) in the DNA. M
## Abstract DNA interstrand crosslinks (ICLs) are induced by a number of bifunctional antitumor drugs such as cisplatin, mitomycin C, or the nitrogen mustards as well as endogenous agents formed by lipid peroxidation. The repair of ICLs requires the coordinated interplay of a number of genome maint