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Mechanism of Mevalonate Pyrophosphate Decarboxylase: Evidence for a Carbocationic Transition State

✍ Scribed by Dhe-Paganon, Sirano; Magrath, Joe; Abeles, Robert H.

Book ID
126274272
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
965 KB
Volume
33
Category
Article
ISSN
0006-2960

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Mevalonate 5-pyrophosphate decarboxylase is involved in the conversion of MevPP to IPP in the biosynthesis of steroids and terpenoids from mevalonate. Based on a hypothetical model of the transition state of this enzymatic transformation we have synthesized novel hydroxyacetyl proline analogs that a