✦ LIBER ✦

Inhibition of mevalonate 5-pyrophosphate decarboxylase by a proline-containing transition state analog

✍ Scribed by Isidoros Vlattas; James Dellureficio; Edmund Ku; Regine Bohacek; Xiaolu Zhang

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 249 KB
Volume: 6
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(96)00374-5

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✦ Synopsis

Mevalonate 5-pyrophosphate decarboxylase is involved in the conversion of MevPP to IPP in the biosynthesis of steroids and terpenoids from mevalonate. Based on a hypothetical model of the transition state of this enzymatic transformation we have synthesized novel hydroxyacetyl proline analogs that are potent inhibitors of the enzyme.