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Kinetic mechanism of pyruvate decarboxylase Evidence for a specific protonation of the enzymic intermediate

✍ Scribed by Joachim Ermer; Alfred Schellenberger; Gerhard Hübner

Book ID
115925933
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
286 KB
Volume
299
Category
Article
ISSN
0014-5793

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✍ Y. S. Chow; H. S. Shin; A. A. Adesina; P. L. Rogers 📂 Article 📅 1995 🏛 Springer Netherlands 🌐 English ⚖ 344 KB

To provide further understanding of the biotransformation of benzaldehyde to L-phenylaeetyl carbinol (L-PAC), an intermediate in L-ephedrine production, a kinetic model has been developed for the deactivation of pyruvate decarboxylase (PDC) by benzaldehyde. The model confirms that deactivation is fi