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A kinetic model for the deactivation of pyruvate decarboxylase (PDC) by benzaldehyde

✍ Scribed by Y. S. Chow; H. S. Shin; A. A. Adesina; P. L. Rogers

Publisher
Springer Netherlands
Year
1995
Tongue
English
Weight
344 KB
Volume
17
Category
Article
ISSN
0141-5492

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✦ Synopsis

To provide further understanding of the biotransformation of benzaldehyde to L-phenylaeetyl carbinol (L-PAC), an intermediate in L-ephedrine production, a kinetic model has been developed for the deactivation of pyruvate decarboxylase (PDC) by benzaldehyde. The model confirms that deactivation is first order with respect to benzaldehyde concentration and exhibits a square root dependency on time. The model covers the range of benzaldehyde concentrations 100-300 mM, as it has been shown previously that 200 mM benzaldehyde can produce L-PAC concentrations up to 190 mM (28.6 g/L) using partially purified PDC from Candida utilis.

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