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Mechanism of inhibition of DNA gyrase by quinolone antibacterials: specificity and cooperativity of drug binding to DNA

✍ Scribed by Shen, Linus L.; Baranowski, John; Pernet, Andre G.

Book ID
120562608
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
832 KB
Volume
28
Category
Article
ISSN
0006-2960

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## Abstract We have studied the bacterial resistance to fluoroquinolones that arises as a result of mutations in the DNA gyrase target protein. Although it is known that DNA gyrase is a target of quinolone antibacterial agents, the molecular details of the quinolone–gyrase interaction remain unclea