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DNA Cleavage Is Not Required for the Binding of Quinolone Drugs to the DNA Gyrase−DNA Complex †

✍ Scribed by Critchlow, Susan E.; Maxwell, Anthony

Book ID
126787856
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
367 KB
Volume
35
Category
Article
ISSN
0006-2960

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✍ Sergio Madurga; Javier Sánchez-Céspedes; Ignasi Belda; Jordi Vila; Ernest Giralt 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 675 KB

## Abstract We have studied the bacterial resistance to fluoroquinolones that arises as a result of mutations in the DNA gyrase target protein. Although it is known that DNA gyrase is a target of quinolone antibacterial agents, the molecular details of the quinolone–gyrase interaction remain unclea