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The Interaction of Drugs with DNA Gyrase: A Model for the Molecular Basis of Quinolone Action

✍ Scribed by Heddle, Jonathan G.; Barnard, Faye M.; Wentzell, Lois M.; Maxwell, Anthony

Book ID
120223421
Publisher
Taylor and Francis Group
Year
2000
Tongue
English
Weight
855 KB
Volume
19
Category
Article
ISSN
0732-8311

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## Abstract We have studied the bacterial resistance to fluoroquinolones that arises as a result of mutations in the DNA gyrase target protein. Although it is known that DNA gyrase is a target of quinolone antibacterial agents, the molecular details of the quinolone–gyrase interaction remain unclea