Mechanism of enhanced lipid peroxidation in the liver of Long-Evans cinnamon (LEC) rats
โ Scribed by Hideki Yamomoto; Kyogo Hirose; Yayoi Hayasaki; Makihiko Masuda; Akio Kazusaka; Shoichi Fujita
- Publisher
- Springer-Verlag
- Year
- 1999
- Tongue
- English
- Weight
- 153 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0340-5761
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๐ SIMILAR VOLUMES
Long Evans Cinnamon (LEC) rats are an inbred strain with a mutation affecting a copper transporter. As a result, hepatic copper levels rise and the rats spontaneously develop hepatitis that is fatal in about 40% of the rats. The rats that die have been reported to develop anti-microsomal antibodies,
To understand the unique pathophysiological process of LEC rats (Long-Evans rats with a cinnamon-like coat color), which develop hereditary and spontaneous hepatic injury โผ4 months after birth, the levels of four biometals, such as Cu, Fe, Zn, and Mn together with metallothionein (MT) and nitric oxi