The Long-Evans Cinnamon rat is a mutant strain that contracts hereditary hepatitis and, eventually, spontaneous hepatoma. Recently, abnormal copper accumulations in Long-Evans Cinnamon rat livers were shown to be genetically linked to the development of hepatitis. Because reduced glutathione and glu
Gene expression in the liver of Long-Evans cinnamon rats during the development of hepatitis
โ Scribed by Dominik Klein; Josef Lichtmannegger; Matthias Finckh; Karl H. Summer
- Publisher
- Springer-Verlag
- Year
- 2003
- Tongue
- English
- Weight
- 195 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0340-5761
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๐ SIMILAR VOLUMES
The Long-Evans Cinnamon rat is a mutant strain that contracts hereditary hepatitis and, eventually, spontaneous hepatocellular carcinoma. Because we found a corresponding gross copper accumulation in the liver of the rats, we examined whether the development of hepatitis in our rat system could be p
Long Evans Cinnamon (LEC) rats are an inbred strain with a mutation affecting a copper transporter. As a result, hepatic copper levels rise and the rats spontaneously develop hepatitis that is fatal in about 40% of the rats. The rats that die have been reported to develop anti-microsomal antibodies,