Accumulation of orally given cadmium in Long-Evans Cinnamon (LEC) rats with an inherently abnormal copper metabolism

D-penicillamine prevents the development

D-penicillamine prevents the development of hepatitis in long-evans cinnamon rats with abnormal copper metabolism

✍ Yuji Togashi; Yu Li; Jong-Hon Kang; Noritoshi Takeichi; Yasunori Fujioka; Kazuo 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 664 KB

The Long-Evans Cinnamon rat is a mutant strain that contracts hereditary hepatitis and, eventually, spontaneous hepatocellular carcinoma. Because we found a corresponding gross copper accumulation in the liver of the rats, we examined whether the development of hepatitis in our rat system could be p