Mechanism of binding of iron to potential therapeutic chelating agents

✍ Scribed by Neil E. Spingarn; Alan C. Sartorelli

• Book ID: 104580000
• Publisher: John Wiley and Sons
• Year: 1980
• Tongue: English
• Weight: 302 KB
• Volume: 18
• Category: Article
• ISSN: 0020-7608
• DOI: 10.1002/qua.560180219

✦ Synopsis

Abstract

To aid in designing new therapeutic iron chelating agents, the mechanism of iron binding to prototypic heterocyclic carboxaldehyde thiosemicarbazones has been studied. Based on molecular orbital and spectroscopic studies, iron (II) is found to bind in a covalent manner, while iron(III) seems to interact ionically. However, with both iron(II) and iron(III), chelate formation is dependent on charge interaction between the metal and the coordinating atoms of the ligand.