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Therapeutic potential of iron chelators in diseases associated with iron mismanagement

✍ Scribed by Eugene D. Weinberg

Book ID
111770526
Publisher
Pharmaceutical Press
Year
2006
Tongue
English
Weight
181 KB
Volume
58
Category
Article
ISSN
2042-7158

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## Abstract To aid in designing new therapeutic iron chelating agents, the mechanism of iron binding to prototypic heterocyclic carboxaldehyde thiosemicarbazones has been studied. Based on molecular orbital and spectroscopic studies, iron (II) is found to bind in a covalent manner, while iron(III)