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Mechanism of action of the aqueous seed extract of Mucuna pruriens on the guinea-pig ileum

โœ Scribed by M. O. Uguru; J. C. Aguiyi; A. A. Gesa

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
75 KB
Volume
11
Category
Article
ISSN
0951-418X

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โœฆ Synopsis

The hot water extract (HWE) of the seed of Mucuna pruriens dose-dependently contracted the guinea-pig ileum. The ED 50 and pD 2 values for the HWE was lower than those of ACh and histamine. Cyproheptadine and promethazine (10 ng/mL) significantly antagonized the effects of histamine, 5-hydroxytryptamine (5-HT) and HWE. Atropine blocked the effect of ACh and partially blocked the HWE. The calcium channel blockers nifedipine and verapamil both blocked the effects of all the agonists including HWE. These results suggest that the HWE contains potent histamine receptor stimulants or principles as it was blocked by low doses of H 1 receptor blockers. It appears that stimulation of the receptors leads to influx of calcium since the effect was also blocked by nifedipine and verapamil. It is likely that it also stimulates muscarinic receptors.

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