Mechanism of Actinomycin Resistance in SV40-Transformed Hamster Cells
β Scribed by Y. Langelier; R. Simard; C. Brailovsky
- Book ID
- 115110654
- Publisher
- John Wiley and Sons
- Year
- 1974
- Tongue
- English
- Weight
- 491 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0301-4681
No coin nor oath required. For personal study only.
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## Abstract The biological properties of a hamster cell line Cl 2 TSVβ5/R derived from an SV40 tumour and made resistant to Actinomycin D (2 ΞΌg/ml) were investigated, in particular: tumorigenicity in vitro growth on plastic or in soft agar, agar, persistence of SV40 specific neoantigens (T and TSTA
## Abstract The expression of the transformed phenotype was studied in segregants from a hybrid cell line resulting from the fusion of SV40βtransformed BHK21 Syrian hamster cells (thioguanine resistant) and 3T3 mouse cells (bromodeoxyuridine resistant). Since the hamster cell parent was sensitive t