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Mechanical load stimulates prostaglandin E2 synthesis by articular cartilage chondrocytes in vitro

✍ Scribed by A.K. MacFarland; A.J. Johnstone; M.J. Gordon; A.K. Dutta-Roy; R.M. Aspden

Book ID
117640418
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
97 KB
Volume
15
Category
Article
ISSN
0945-053X

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## Abstract Short‐term incubations of intact canine articular cartilage slices with prostaglandins E~1~ and E~2~ caused significant losses of hexosamine from cartilage matrix compared to controls. Chloroquine, an inhibitor of DNA primer, prevented this prostaglandin‐induced hexosamine depletion. Th