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In vitro hexosamine depletion of intact articular cartilage by e-prostaglandins

✍ Scribed by John P. Fulkerson; Inge-Maria Ladenbauer-Bellis; O. Donald Chrisman

Publisher: John Wiley and Sons
Year: 1979
Tongue: English
Weight: 403 KB
Volume: 22
Category: Article
ISSN: 0004-3591
DOI: 10.1002/art.1780221011

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Short‐term incubations of intact canine articular cartilage slices with prostaglandins E~1~ and E~2~ caused significant losses of hexosamine from cartilage matrix compared to controls. Chloroquine, an inhibitor of DNA primer, prevented this prostaglandin‐induced hexosamine depletion. These data suggest that E‐prostaglandins may degrade articular cartilage directly through DNA‐dependent RNA synthesis of cathepsinlike proteases. Catabolism of articular cartilage probably involves degradation of existing matrix in addition to inhibition of synthesis.

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