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Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage

✍ Scribed by P.A. Torzilli; M. Bhargava; S. Park; C.T.C. Chen

Book ID
113733041
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
541 KB
Volume
18
Category
Article
ISSN
1063-4584

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✍ Vishwas Ganu; Ronald Goldberg; Jane Peppard; John Rediske; Richard Melton; Shou- πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 918 KB

Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti