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Inhibition of Articular Cartilage Degradation in Culture by a Novel Nonpeptidic Matrix Metalloproteinase Inhibitor

โœ Scribed by R. CLARK BILLINGHURST; KEVIN O'BRIEN; A. ROBIN POOLE; C. WAYNE McILWRAITH


Book ID
111395061
Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
380 KB
Volume
878
Category
Article
ISSN
0890-6564

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Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti