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Inhibition of Cartilage Degradation and Changes in Physical Properties Induced by IL-1β and Retinoic Acid Using Matrix Metalloproteinase Inhibitors

✍ Scribed by Lawrence J. Bonassar; John D. Sandy; Michael W. Lark; Anna H.K. Plaas; Eliot H. Frank; Alan J. Grodzinsky

Book ID
115566606
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
439 KB
Volume
344
Category
Article
ISSN
0003-9861

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Inhibition of interleukin-1α-induced cartilage oligomeric matrix protein degradation in bovine articular cartilage by matrix metalloproteinase inhibitors: Potential role for matrix metalloproteinases in the generation of cartilage oligomeric matrix protein fragments in arthritic synovial fluid
✍ Vishwas Ganu; Ronald Goldberg; Jane Peppard; John Rediske; Richard Melton; Shou- 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 918 KB

Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti