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Differential recovery of glycosaminoglycan after IL-1-induced degradation of bovine articular cartilage depends on degree of degradation

✍ Scribed by Ashley Williams, Rachel A Oppenheimer, Martha L Gray…


Book ID
120707896
Publisher
BioMed Central
Year
2003
Tongue
English
Weight
1000 KB
Volume
5
Category
Article
ISSN
1478-6354

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Objective. To determine whether matrix metalloproteinases (MMPs) degrade cartilage oligomeric matrix protein (COMP) to produce fragments similar to those found in synovial fluid (SF) from patients with arthritis. Methods. COMP fragments were generated in vitro by treating (a) bovine articular carti