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Measurement of the FMOC loading of protected amine-functionalised polymer beads

✍ Scribed by C.E. Freeman; A.G. Howard

Book ID
116900812
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
75 KB
Volume
65
Category
Article
ISSN
0039-9140

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πŸ“œ SIMILAR VOLUMES

A new polymer-supported reagent for the
A new polymer-supported reagent for the Fmoc-protection of amino acids
✍ Rafael Chinchilla; David J Dodsworth; Carmen NΓ‘jera; JosΓ© M Soriano πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 French βš– 58 KB

A new polymer-supported Fmoc-OSu (Fmoc-P-OSu) has been prepared from polymer-bound N-hydroxysuccinimide (P-HOSu), and used as a solid-supported reagent for the Fmoc-protection of amino groups. The residual P-HOSu generated after the protection reaction can be separated by simple filtration and reuse

Direct conversion of Fmoc-protected amin
Direct conversion of Fmoc-protected amines into O-alkyl carbamates by the Mitsunobu reaction: a practical strategy for the solid-phase synthesis of carbamates
✍ Florencio Zaragoza; Henrik Stephensen πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 95 KB

Support-bound, Fmoc-protected amines react with aliphatic alcohols in the presence of ADDP, PBu 3 , and DIPEA to yield O-alkyl carbamates. The reaction presumably proceeds via O-alkylation of an intermediate carbamate anion.