✦ LIBER ✦

Measurement of relative regional tumor blood flow in mice by deuterium NMR imaging

✍ Scribed by Jeffrey L. Evelhoch; Jacqueline B. Larcombe McDouall; James Mattiello; Nicholas E. Simpson

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 743 KB
Volume: 24
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910240105

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A noninvasive method to measure relative regional tumor blood flow (rTBF) throughout murine tumors which uses deuterium NMR imaging to observe regional uptake of HOD after bolus iv injection of D~2~O is introduced. HOD uptake images are formed by subtraction of a background (preinjection) image from 94‐s gradient‐refocused deuterium NMR images acquired starting 30 s and 10 min after D~2~O injection. The pixel intensity in the HOD uptake image acquired starting 30 s after injection is directly related to rTBF with a limit of detection estimated at 7 ml/(100 g‐min). The image acquired 10 min after D~2~O injection extends the estimated limit of detection for rTBF to 3 ml/(100 g‐min). Heterogeneity in rTBF and regional effects of photodynamic therapy within RIF‐1 tumors are readily perceived. This method may provide a valuable tool to further our understanding of the relationship between blood flow and therapeutic response in tumors. © 1992 Academic Press, Inc.

📜 SIMILAR VOLUMES

Measurement of tumor blood flow by deute

Measurement of tumor blood flow by deuterium NMR and the effects of modifiers

✍ Jeffrey L. Evelhoch 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 661 KB

Tumor metabolism is directly coupled to tumor blood flow (TBF) and both metabolism and blood flow may be determinants of tumor response to treatment. Since NMR has been used extensively to monitor tumor metabolism noninvasively, development of NMR-based methods for TBF measurement was motivated by t

Measurement of regional cerebral blood f

Measurement of regional cerebral blood flow in cat brain using intracarotid 2H2O and 2H NMR imaging

✍ J. A. Detre; V. H. Subramanian; M. D. Mitchell; D. S. Smith; A. Kobayashi; A. Za 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 406 KB

## Abstract Cerebral blood flow (CBF) was measured in cat brain __in vivo__ at 2.7 T using ^2^H NMR to monitor the washout of deuterated saline injected into both carotid arteries via the lingual arteries. In anesthetized cats, global CBF varied directly with __P__aCO~2~ over a range of 20‐50 mm Hg

Measurement of cerebral blood flow in ra

Measurement of cerebral blood flow in rat brain by 19F-NMR detection of trifluoromethane washout

✍ John A. Detre; Clifford J. Eskey; Alan P. Koretskyp 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 676 KB

## Abstract The washout of trifluoromethane (CHF~3~) from rat cerebral cortex was monitored by ^19^F NMR. After 15 min of inhalation of 67% CHF~3~/33% O2 the fluorine signal detected was in a steady state. The CHF~3~ was switched off rapidly at the endotracheal tube and the washout detected with 12

1H NMR spectroscopy of subcutaneous tumo

1H NMR spectroscopy of subcutaneous tumors in mice: Preliminary studies of effects of growth, chemotherapy and blood flow reduction

✍ Dikoma C. Shungu; Zaver M. Bhujwalla; Janna P. Wehrle; Jerry D. Glickson 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 862 KB

This study evaluates a number of methods for obtaining 'H NMR spectra with adequate suppression of lipid and water resonances in two subcutaneously implanted transplantable tumor models (RIF-1 and EMT6/SF). Spin-echo spectra with long TEs (270 ms; water suppressed by presaturation) eliminated lipid

Imaging H217O distribution in a phantom

Imaging H217O distribution in a phantom and measurement of metabolically produced H217O in live mice by proton NMR

✍ Itamar Ronen; Jing-Huei Lee; Hellmut Merkle; Kamil Ugurbil; Gil Navon 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 327 KB

Previously we suggested a method for indirect detection of H 2 17 O via a combination of 1 H spin-echo sequence and 17 O decoupling. The method is based on the shortening of the water proton T 2 due to the residual spin-spin coupling with the 17 O nucleus, and on our finding that this shortening is

Effects of blood flow modifiers on tumor

Effects of blood flow modifiers on tumor metabolism observed in vivo by proton magnetic resonance spectroscopic imaging

✍ Zaver M. Bhujwalla; Dikoma C. Shungu; Jerry D. Glickson 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 865 KB

## Abstract Perfusion plays a key role in tumor proliferation and therapeutic response. Tumor heterogeneity necessitates use of the highest spatial resolution to monitor metabolic correlates of blood flow changes. This is best achieved with ^1^H NMR spectroscopy, which permits noninvasive acquisiti