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Measurement of regional cerebral blood flow in cat brain using intracarotid 2H2O and 2H NMR imaging

✍ Scribed by J. A. Detre; V. H. Subramanian; M. D. Mitchell; D. S. Smith; A. Kobayashi; A. Zaman; J. S. Leigh Jr.

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 406 KB
Volume: 14
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910140223

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Cerebral blood flow (CBF) was measured in cat brain in vivo at 2.7 T using ^2^H NMR to monitor the washout of deuterated saline injected into both carotid arteries via the lingual arteries. In anesthetized cats, global CBF varied directly with __P__aCO~2~ over a range of 20‐50 mm Hg, and the corresponding global CBF values ranged from 25 to 125 ml‐100 g^−1^min^−1^. Regional CBF was measured in a 1‐cm axial section of cat brain using intracarotid deuterated saline and gradient‐echo ^2^H NMR imaging. Blood flow images with a maximum pixel resolution of 0.3 × 0.3 × 1.0 cm were generated from the deuterium signal washout at each pixel. Image derived values for CBF agreed well with other determinations, and decreased significantly with hypocapnia. © 1990 Academic Press, Inc.

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