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Measurement of methimazole in human plasma using gas-liquid chromatography

✍ Scribed by M.R. Bending; D. Stevenson

Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
328 KB
Volume
154
Category
Article
ISSN
1873-3778

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✦ Synopsis

Three group~'-~ have independently investigated the metabolic clearan* of antipyrine in thyroid disease in man. Each study demonstrates an increased clearance of antipyrine in hyperthyroidism and a reduced clearance in hypothyroidism when compared with the euthyroid (normal) state. MethimazoIe (1-methyl-2-me~ptoimidazole; MMI) is the active metabolite of carbimazole (I-methyl-2-mercapto-3catbethoxyimidazole; CBZ), a drug commonly used to control hyperthyroidism in man (Fig. 1).

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