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Measurement of Homonuclear Proton Couplings from Regular 2D COSY Spectra

โœ Scribed by Frank Delaglio; Zhengrong Wu; Ad Bax

Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
211 KB
Volume
149
Category
Article
ISSN
1090-7807

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โœฆ Synopsis

An interactive computer procedure is described which determines (1)H--(1)H couplings from fitting the cross-peak multiplets in regular phase-sensitive COSY spectra. The robustness and simplicity of the method rely on the fact that a given cross-peak intensity is not an independent variable in the fitting procedure, making it possible to measure couplings accurately even from individual cross peaks with unresolved multiplet structure.

๐Ÿ“œ SIMILAR VOLUMES

Measurement of Homonuclear Proton Coupli
Measurement of Homonuclear Proton Couplings Based on Cross-Peak Nulling in CT-COSY
โœ Zhengrong Wu; Ad Bax ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 427 KB

A method in which 1 H-1 H scalar and dipolar couplings are obtained from the cross-peak nulling condition in a series of constanttime (CT) COSY spectra, as a function of the duration of the CT period, is described. The method is best suited for measurement of 1 H-1 H couplings in the range 5-20 Hz.