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Measurement of blood-brain barrier permeability using dynamic Gd-DTPA scanning—a comparison of methods

✍ Scribed by H. B. W. Larsson; P. S. Tofts

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
172 KB
Volume
24
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Two recently published methods of blood‐brain barrier permeability measurement using Gd‐DTPA scanning are compared by authors representing each group. The physiological models are reconciled. Results from both groups agree. These show that the transfer constant (the permeability surface area product per unit volume of tissue) of the defective blood‐brain barrier in multiple sclerosis is in the range 1‐12·10^−4^s^−1^ © 1992 Academic Press, Inc.

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