Measurement of blood-brain barrier permeability in a tumor model using magnetic resonance imaging with gadolinium-dtpa

✍ Scribed by James Kenney; Udo Schmiedl; Kenneth Maravilla; Frank Starr; Michael Graham; Alexander Spence; James Nelson

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 510 KB
• Volume: 27
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.1910270108

✦ Synopsis

Abstract

Sequential MR imaging with gadolinium‐diethylenetriaminepentaacetic acid (Gd‐DTPA) and sequential measurements of plasma Gd‐DTPA concentration by inductively coupled plasma atomic emission spectroscopy (ICP‐AES) were used to estimate the blood‐to‐tissue transport coefficient (K~i~) in the 36B‐10 rat glioma model. For these measurements, tissue Gd‐DTPA concentration was estimated from tumor enhancement by correlation with calibration measurements obtained by ICP‐AES analysis of tumor tissue. The 14 animals for which K~i~, was calculated can be grouped into those imaged at 11 days following tumor implantation, at 13‐18 days, and at 20 days. The mean (+SEM) K~i~ values for these groups were 1.1 + 0.24, 9.2 + 0.8, and 13.4 + 1.7 ml/kg‐min, respectively. These results correspond well with published data obtained by quantitative autoradiography. It is concluded that frequent sequential imaging and a graphical approach to K~i~, calculation are promising methods for determining the blood‐to‐tissue transport coefficient noninvasively by contrastenhanced MRI.