## Abstract Breakdown of the bloodโbrain barrier (BBB), occurring in many neurological diseases, has been difficult to measure noninvasively in humans. Dynamic contrastโenhanced magnetic resonance imaging measures BBB permeability. However, important technical challenges remain and normative data f
Quantitative measurement of blood-brain barrier permeability in human using dynamic contrast-enhanced MRI with fast T1 mapping
โ Scribed by Saeid Taheri; Charles Gasparovic; Nadim Jon Shah; Gary A. Rosenberg
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 478 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
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## Abstract Dynamic contrastโenhanced MRI is used to estimate microvascular parameters by tracer kinetics analysis. The time for the contrast agent to travel from the artery to the tissue of interest (bolus arrival time (BAT)) is an important parameter that must be measured in such studies because
## Abstract ## Purpose To measure the cerebrovascular volume and bloodโbrain barrier (BBB) permeability indices in hippocampus and cerebellum of patients with mild cognitive impairment (MCI) using dynamic contrastโenhanced MRI (DCEโMRI), and compare to that of normal controls. ## Materials and Me