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MDMX regulation of p53 response to ribosomal stress

โœ Scribed by Gilkes, Daniele M; Chen, Lihong; Chen, Jiandong

Book ID
110031806
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
593 KB
Volume
25
Category
Article
ISSN
0261-4189

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Oxidative stress to mammalian cells causes cellular damage and triggers inducible cellular responses leading to cell death by apoptosis. In this paper, we report that p53 was required for programmed cell death induced by oxidative stress in both mouse and human cells and that p53 transactivation was