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Regulation of p53 in response to DNA damage

✍ Scribed by Lakin, Nicholas D; Jackson, Stephen P


Book ID
110062402
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
340 KB
Volume
18
Category
Article
ISSN
0950-9232

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## Abstract The tumor suppressor p53 plays a central role in the DNA damage response. After exposure to genotoxic stress, p53 can both positively and negatively regulate cell fate. Initially, p53 promotes cell survival by inducing cell cycle arrest, DNA repair, and other pro‐survival pathways. Howe