Matrix metalloproteinase and cytokine production by bone marrow adherent cells from multiple myeloma patients
✍ Scribed by Barbara Zdzisińska; Adam Walter-Croneck; Anna Dmoszyńska; Martyna Kandefer-Szerszeń
- Publisher
- Springer
- Year
- 2006
- Tongue
- English
- Weight
- 299 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0004-069X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
We have investigated the production of metalloproteinases (MMP-1, MMP-2, MMP-9) and tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) in bone marrow stromal cells (BMSCs) of patients with multiple myeloma (MM) and a healthy control. The new findings of this paper is that BMSCs of the MM pa
## Abstract MM is a B‐cell malignancy mainly characterized by monoclonal expansion of plasma cells in the BM, presence of paraprotein in serum and occurrence of osteolytic bone lesions. MMPs are a family of proteolytic enzymes that can contribute to cancer growth, invasion, angiogenesis, bone degra
## Abstract Natural killer (NK) cells are cytotoxic lymphocytes able to kill tumor cells and virus‐infected cells. Human‐resting NK cells can be activated by co‐culture with NK‐resistant CTV‐1a cells. These tumor‐activated cells (TaNKs) are cytotoxic to a range of NK‐resistant tumor cells in vitro.
## Background Erythroid nuclear cells (ENC) of the bone marrow (BM) have not previously been considered as important producers of wide spectrum of haemo- and immunoregulatory cytokines. The aim of the current work was to confirm the production of the main hemo- and immunoregulatory cytokines in hum