✦ LIBER ✦

Matrix Effects on the Fragmentation of Vitamin B12 in Plasma Desorption Mass Spectrometry

✍ Scribed by J. F. Blankenship; M. J. VanStipdonk; E. A. Schweikert

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 156 KB
Volume: 11
Category: Article
ISSN: 0951-4198
DOI: 10.1002/(sici)1097-0231(19970115)11:1<143::aid-rcm814>3.0.co;2-z

No coin nor oath required. For personal study only.

✦ Synopsis

A continuing effort in mass spectrometry is to optimize desorption/ionization processes in order to enhance analyte ion yields and reduce fragmentation. The effect of small carbohydrate and amino acid matrices on the yield of secondary ions from vitamin B 12 (cyanocobalamin) was examined using plasma desorption mass spectrometry. The extent of the corrin decomposition is dependent upon the matrix-to-analyte ratio. The enhanced yields of the high-mass fragment ion [M-CN + H] + and the ions corresponding to protonated molecules, however, are dependent upon both the matrix-to-analyte ratio and the nature of the matrix.

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