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Matrix-assisted laser desorption/ionization for short tandem repeat loci

✍ Scribed by N. I. Taranenko; V. V. Golovlev; S. L. Allman; N. V. Taranenko; C. H. Chen; J. Hong; L. Y. Chang

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 155 KB
Volume: 12
Category: Article
ISSN: 0951-4198
DOI: 10.1002/(sici)1097-0231(19980430)12:8<413::aid-rcm175>3.0.co;2-c

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✦ Synopsis

Matrix-assisted laser desorption/ionization was used for the detection of four base short tandem repeats (STR) for clinical samples using a time-of-flight mass spectrometer. Since STR plays an important role in genetic disease and human identification, this work indicates that laser desorption mass spectrometry has the potential to achieve rapid DNA typing for both forensic applications and genetic disease diagnosis.

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