Matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a powerful tool for the mass and sequence analysis of natural and modified oligonucleotides
✍ Scribed by Pieles, Uwe; Zürcher, Werner; Schär, Martin; Moser, Heinz
- Book ID
- 111886799
- Publisher
- Oxford University Press
- Year
- 1993
- Tongue
- English
- Weight
- 476 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0305-1048
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Oligonucleotide sequencing by fragmentation in matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry has been demonstrated. With this sequencing method, the preparation of oligonucleotide ladder products and gel electrophoresis are not required, thus the sequencing
The ionization of nucleosides in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry was systematically investigated using adenine (A), thymine (T), guanine (G) and cytosine (C) with several common matrices. Experimental results of the protonation and deprotonation of the ba
This study presents matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOFMS) as a powerful tool to analyze and characterize oligonucleotides covalently linked to a solid support during their synthesis. The analysis of the fragment ions generated either in negative o