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Matrilysin gene expression in sporadic and familial colorectal adenomas

✍ Scribed by Nobumichi Takeuchi; Yasushi Ichikawa; Takashi Ishikawa; Nobuyoshi Momiyama; Satoshi Hasegawa; Yoji Nagashima; Kaoru Miyazaki; Naohiko Koshikawa; Masato Mitsuhashi; Hiroshi Shimada

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 96 KB
Volume: 19
Category: Article
ISSN: 0899-1987
DOI: 10.1002/(sici)1098-2744(199708)19:4<225::aid-mc2>3.0.co;2-b

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✦ Synopsis

We examined the expression of matrilysin mRNA in sporadic and hereditary colorectal adenomas to clarify the role of matrilysin in tumorigenesis. Matrilysin mRNA was not detected in normal colorectal mucosa from patients with either sporadic or familial adenomas. Matrilysin mRNA expression in sporadic adenomas correlated with the degree of dysplasia and the size of the mass, whereas most of the adenomas in patients with familial adenomatous polyposis coli expressed matrilysin mRNA irrespective of adenoma size or degree of dysplasia. Because matrilysin is more likely to be expressed in adenomas with a potential for malignancy, this enzyme may play a role in the malignant conversion of colorectal adenomas.

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